Chlorosuccinimide → 2-Amino-4-(5-chloro-furan-2-yl)-6-(3-methyl-pyridin-2-yl-methoxy)-pyrimidine-5-carbonitrile

HRID 1356192Notes

Reaction equation

HRID 1356192 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([O:15][CH2:16][C:17]2[C:22]([CH3:23])=[CH:21][CH:20]=[CH:19][N:18]=2)[N:3]=1.[Cl:24]N1C(=O)CCC1=O>CN(C=O)C>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][C:10]([Cl:24])=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([O:15][CH2:16][C:17]2[C:22]([CH3:23])=[CH:21][CH:20]=[CH:19][N:18]=2)[N:3]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 98361982-Amino-4-furan-2-yl-6-(3-methyl-pyridin-2-ylmethoxy)-pyrimidine-5-carbonitrile

Product 1

HCID 185076352-Amino-4-(5-chloro-furan-2-yl)-6-(3-methyl-pyridin-2-yl-methoxy)-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 2-amino-4-furan-2-yl-6-(3-methyl-pyridin-2-ylmethoxy)-pyrimidine-5-carbonitrile and N-chlorosuccinimide in DMF. ES-MS m/e (%): 344 (M{37Cl}+H+, 35), 342 (M{35Cl}+H+, 100).

Sources & evidence

ORD record
ord-2e2c7cdd39a2411ea41bfbd918b4a35e
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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