HCID 18509176, compound → HCID 18509173, compound

HRID 1356565Notes

Reaction equation

HRID 1356565 reaction equation
[CH:1]1([C:6]2[C:7]([C:26]([O:28][CH3:29])=[O:27])=[C:8]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[C:9]3[C:10](=[O:18])[CH2:11][C:12]([CH3:17])([CH3:16])[CH2:13][C:14]=3[CH:15]=2)[CH2:5][CH2:4][CH:3]=[CH:2]1>CCOC(C)=O.[Pd]>[CH:1]1([C:6]2[C:7]([C:26]([O:28][CH3:29])=[O:27])=[C:8]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[C:9]3[C:10](=[O:18])[CH2:11][C:12]([CH3:17])([CH3:16])[CH2:13][C:14]=3[CH:15]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 18509176HCID 18509176, compound

Product 1

HCID 18509173HCID 18509173, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1.17 g (2.98 mmol) of the compound of Example XVI and 150 mg of Pd/C (10%) in 80 ml of EtOAc is hydrogenated under an atmosphere of hydrogen (1 atm) for 5 h. The mixture is filtered through diatomaceous earth, concentrated and purified over silica gel 60 (EtOAc/petroleum ether 1:10).

Workup

  1. filtrationThe mixture is filtered through diatomaceous earth
  2. concentrationconcentrated
  3. custompurified over silica gel 60 (EtOAc/petroleum ether 1:10)

Sources & evidence

ORD record
ord-4fdd03248fc546e2a9e5e6d0ca21962e
Source dataset
uspto-grants-2003_07
Patent number
US06586613B1

Reaction notes

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