反应详情

温度

20 °C

Racemic cis-1-amino-2-indanol (66.6 g, water wet, content 81.1%) was dissolved in 180 ml of methanol with 10 ml of DMF at reflux. Then 65 g of (R,R)-tartaric acid dissolved in 200 ml of methanol were added. Stirring of the mixture was continued for one hour at reflux and then it was cooled down again to 20° C. and isolation by filtration was effected. The solid was washed twice with 120 ml of methanol. After drying, 54.8 g of (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate were obtained with an e.e. of 97.0%.

1. temperatureat reflux
2. additionwere added
3. temperatureat reflux
4. filtrationisolation by filtration
5. washThe solid was washed twice with 120 ml of methanol
6. customAfter drying