Hydrochloric Acid → HCID 18509502, compound

HRID 1356814Notes

Reaction equation

HRID 1356814 reaction equation
[CH3:1][C:2]([CH3:21])([CH3:20])[C:3]#[C:4]/[CH:5]=[CH:6]/[CH2:7][N:8]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]([CH3:19])=[CH2:18])[CH3:9].[ClH:22].C(OCC)(=O)C>>[ClH:22].[CH3:1][C:2]([CH3:21])([CH3:20])[C:3]#[C:4]/[CH:5]=[CH:6]/[CH2:7][N:8]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]([CH3:19])=[CH2:18])[CH3:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 18509387HCID 18509387, compound

Product 1

HCID 18509502HCID 18509502, compoundYield 91%

Procedure

The procedure described in Example 19 was repeated, except that Compound 38 (360 mg; 1.28 mmol) and hydrogen chloride in ethyl acetate (4 N: 0.35 ml; 1.4 mmol) were used, to thereby yield 370 mg of the target compound (yield: 91.0%).

Sources & evidence

ORD record
ord-95037d762118453eba64c9800b9fdbac
Source dataset
uspto-grants-2003_07
Patent number
US06586633B1

Reaction notes

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