Isopropylamine → HCID 18509452, compound

HRID 1356815Notes

Reaction equation

HRID 1356815 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].Br[CH2:6][C:7]1[CH:8]=[C:9]([C:13](=[O:15])[CH3:14])[CH:10]=[CH:11][CH:12]=1>C(N(CC)CC)C>[CH:1]([NH:4][CH2:6][C:7]1[CH:8]=[C:9]([C:13](=[O:15])[CH3:14])[CH:10]=[CH:11][CH:12]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 154798071-(3-(Bromomethyl)phenyl)ethan-1-one

Product 1

HCID 18509452HCID 18509452, compoundYield 69.9%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Referential Example 4 was repeated, except that isopropylamine (instead of triethylamine) (11.82 g; 200 mmol) and 3′-bromomethylacetophenone (4.26 g; 20 mmol) were used, to thereby yield 2.67 g of the target compound (yield: 69.9%).

Sources & evidence

ORD record
ord-a32234aca39344629654e65ccc48d9fe
Source dataset
uspto-grants-2003_07
Patent number
US06586633B1

Reaction notes

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