HCID 18504786, compound → HCID 13931389, compound

HRID 1356997Notes

Reaction equation

HRID 1356997 reaction equation
[C:1]([N:5]([CH3:15])[C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1)(=[O:4])[CH2:2][CH3:3]>C1COCC1.[Pd]>[C:1]([N:5]([CH3:15])[C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1)(=[O:4])[CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 18504786HCID 18504786, compound

Product 1

HCID 13931389HCID 13931389, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The reaction is carried out using an analogous method to (9b), using N-propionyl-N-methyl-4-nitroaniline (10a)(6.8 g, 32.86 mmol), 10%Pd on carbon (447 mg) in THF (75 ml). The hydrogenation yields an oil. ES+ (M+1) 178.87.

Workup

  1. customThe hydrogenation yields an oil

Sources & evidence

ORD record
ord-d933b64494b546c887d8d9dec84f21ca
Source dataset
uspto-grants-2003_07
Patent number
US06589950B1

Reaction notes

Loading…