Phosphorus oxychloride → HCID 18504828, compound

HRID 1357013Notes

Reaction equation

HRID 1357013 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:14][CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][O:17]2)=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=O)[NH:8][N:7]=[CH:6]2.P(Cl)(Cl)([Cl:24])=O>>[Cl:24][C:9]1[C:10]2[C:5](=[C:4]([O:14][CH2:15][CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][O:17]3)[C:3]([O:2][CH3:1])=[CH:12][CH:11]=2)[CH:6]=[N:7][N:8]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 18504806HCID 18504806, compound

Product 1

HCID 18504828HCID 18504828, compound

Procedure

Operating analogously to example 7 staring from 6-methoxy-5-(tetrahydropyran-2-yl-methoxy)-2H-phthalazin-1-one (1.48 g, 5.12 mmoles), obtained as described in example 42, and phosphoryl chloride (6 ml) 1.65 g of the title product as a crude were obtained and used as such in the next step.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-dcb966d869a04205866ed7871594bf49
Source dataset
uspto-grants-2003_07
Patent number
US06589951B1

Reaction notes

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