Phosphorus oxychloride → HCID 18504791, compound

HRID 1357015Notes

Reaction equation

HRID 1357015 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:14][CH:15]2[CH2:19][CH2:18][O:17][CH2:16]2)=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=O)[NH:8][N:7]=[CH:6]2.P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:9]1[C:10]2[C:5](=[C:4]([O:14][CH:15]3[CH2:19][CH2:18][O:17][CH2:16]3)[C:3]([O:2][CH3:1])=[CH:12][CH:11]=2)[CH:6]=[N:7][N:8]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 18504808HCID 18504808, compound

Product 1

HCID 18504791HCID 18504791, compoundYield 88%

Procedure

Operating analogously to example 7 starting from 6-methoxy-5-(tetrahydro-furan-3-yloxy)-2H-phthalazin-1-one (1.73 g, 6.6 mmoles) and phosphoryl chloride (6.7 ml, 73 mmoles), 1.63 g of the title product were obtained (yield: 88%).

Sources & evidence

ORD record
ord-fd6ce255ff3e4ccca234ac553ae3d41e
Source dataset
uspto-grants-2003_07
Patent number
US06589951B1

Reaction notes

Loading…