Lithium hydroxide, monohydrate → HCID 178512552, compound

HRID 1357072Notes

Reaction equation

HRID 1357072 reaction equation
O.[OH-].[Li+].[C:4]([NH:12][CH:13]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][S:27]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([NH:36][C:37]([NH2:39])=[NH:38])[CH:31]=2)(=[O:29])=[O:28])[CH:21]=1)[CH2:14][C:15]([O:17]CC)=[O:16])(=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>O.C1COCC1>[C:4]([NH:12][CH:13]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][S:27]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([NH:36][C:37]([NH2:39])=[NH:38])[CH:31]=2)(=[O:29])=[O:28])[CH:21]=1)[CH2:14][C:15]([OH:17])=[O:16])(=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 178472066HCID 178472066, compound

Product 1

HCID 178512552HCID 178512552, compoundYield 55%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

94 mg of lithium hydroxide monohydrate were added to a solution of 298.5 mg of (4f) in 30 ml of water and 30 ml of THF. The reaction mixture was stirred at room temperature for 20 h and then concentrated. Chromatographic purification on silica gel (acetonitrile/water=7:1) afforded a white solid (yield: 155 mg).

Workup

  1. concentrationconcentrated
  2. customChromatographic purification on silica gel (acetonitrile/water=7:1)

Sources & evidence

ORD record
ord-5a60fe4da0d94d4ab4415cbed0764598
Source dataset
uspto-grants-2003_07
Patent number
US06589972B2

Reaction notes

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