HCID 18505628, compound → HCID 54736003, compound

HRID 1357206Notes

Reaction equation

HRID 1357206 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[O:15][C:14](=[O:16])[C:13]([CH3:17])=[C:12]([O:18]COC)[C:11]=3[CH3:22])=[CH:7][C:6]=2[CH:23]=1>Cl.C1COCC1>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[O:15][C:14](=[O:16])[C:13]([CH3:17])=[C:12]([OH:18])[C:11]=3[CH3:22])=[CH:7][C:6]=2[CH:23]=1

Participants

4

Reactant 1

HCID 18505628HCID 18505628, compound

Product 1

HCID 54736003HCID 54736003, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 8028TetrahydrofuranSolvent

Procedure

THF (20 ml) was added to and stirred with 6-(5-aminobenzofuran-2-yl)-3,5-dimethyl-4-methoxymethoxy-2H-pyran-2-one (58 mg), one drop of concentrated hydrochloric acid was added and the mixture was stirred at room temperature for one hour. The reaction solution was concentrated under reduced pressure and the residue was purified by thin-layer chromatography (n-hexane/AcOEt =1/1) to obtain 6-(5-aminobenzofuran-2-yl)-3,5-dimethyl-4-hydroxy-2H-pyran-2-one.

Workup

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customthe residue was purified by thin-layer chromatography (n-hexane/AcOEt =1/1)

Sources & evidence

ORD record
ord-f238a10144954d8ea0ff337f89be469e
Source dataset
uspto-grants-2003_07
Patent number
US06589984B1

Reaction notes

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