Triethylamine → HCID 131723975, compound

HRID 1357514Notes

Reaction equation

HRID 1357514 reaction equation
[S:1](Cl)(Cl)=[O:2].O[C@:6]1([C:16]([O:18][CH3:19])=[O:17])[CH2:11][C@@H:10]([CH:12]=[CH2:13])[C@H:9]([OH:14])[C@H:8]([OH:15])[CH2:7]1.C(N(CC)CC)C>ClCCl>[CH:12]([C@H:10]1[C@@H:9]2[O:14][S:1](=[O:2])[O:15][C@@H:8]2[CH:7]=[C:6]([C:16]([O:18][CH3:19])=[O:17])[CH2:11]1)=[CH2:13]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 59076541HCID 59076541, compound

Product 1

HCID 131723975HCID 131723975, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride can be added dropwise to a 0° C. solution of Example 17F and triethylamine in dichloromethane. After stirring for 30 minutes, the reaction mixture can be washed with saturated NaHCO3 solution, and brine, dried (MgSO4) filtered and concentrated to afford the crude desired product.

Workup

  1. washthe reaction mixture can be washed with saturated NaHCO3 solution, and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-ddd6e50730c24dbba600a78129067b7e
Source dataset
uspto-grants-2003_07
Patent number
US06593314B1

Reaction notes

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