Triethylamine → HCID 91569368, compound

HRID 1357516Notes

Reaction equation

HRID 1357516 reaction equation
CS(Cl)(=O)=O.C(O[C@H:15]1[C@H:20]([O:21][S:22]([CH3:25])(=[O:24])=[O:23])[C@@H:19]([N:26]=[N+:27]=[N-:28])[CH:18]=[C:17]([C:29]([O:31][CH3:32])=[O:30])[CH2:16]1)(=O)C1C=CC=CC=1.[CH2:33](N(CC)CC)[CH3:34]>ClCCl>[N:26]([C@@H:19]1[C@@H:20]([O:21][S:22]([CH3:25])(=[O:23])=[O:24])[C@H:15]([CH:33]=[CH2:34])[CH2:16][C:17]([C:29]([O:31][CH3:32])=[O:30])=[CH:18]1)=[N+:27]=[N-:28]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 131723976HCID 131723976, compound

Product 1

HCID 91569368HCID 91569368, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methanesulfonyl chloride can be added dropwise to a 0° C. solution of Example 13H and triethylamine in dichloromethane. The reaction mixture can be stirred for 2 hours, washed with saturated NaHCO3 solution, brine, dried (MgSO4), filtered and concentrated. The concentrate can be purified by flash chromatography to afford the desired product.

Workup

  1. washwashed with saturated NaHCO3 solution, brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated
  5. concentrationThe concentrate can
  6. custombe purified by flash chromatography

Sources & evidence

ORD record
ord-6f475ed5d2df43788bb37efc5cfbb0db
Source dataset
uspto-grants-2003_07
Patent number
US06593314B1

Reaction notes

Loading…