Sodium hydride → HCID 18186829, compound

HRID 1357574Notes

Reaction equation

HRID 1357574 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[F:9][C:10]([F:20])([F:19])[C:11]1[CH:18]=[CH:17][C:14]([CH2:15][OH:16])=[CH:13][CH:12]=1.[H-].[Na+]>>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:16][CH2:15][C:14]2[CH:13]=[CH:12][C:11]([C:10]([F:9])([F:19])[F:20])=[CH:18][CH:17]=2)[N:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 676844-(Trifluoromethyl)benzenemethanolHCID 785042,6-Dichloropyrazine

Product 1

HCID 18186829HCID 18186829, compoundYield 93.5%

Procedure

The title compound was prepared according to the procedure of example 4, step 1 starting from 2,6-dichloropyrazine (444 mg, 3.00 mmol) and 4-trifluoromethylbenzyl alcohol (581 mg, 3.30 mmol) and NaH (55% in mineral oil, 144 mg, 3.30 mmol). Recrystallization from hexane gave 0.81 g (93%) of the title compound: mp 67-69° C. MS m/z 289 (M+H)+. Anal. (C12H8ClF3N2O) C, H, N.

Workup

  1. customThe title compound was prepared
  2. customRecrystallization from hexane

Sources & evidence

ORD record
ord-5fceba38b2894897a759756decdbf2b2
Source dataset
uspto-grants-2003_07
Patent number
US06593330B2

Reaction notes

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