Hydrazine hydrate (1:1) → HCID 18187426, compound

HRID 1357767Notes

Reaction equation

HRID 1357767 reaction equation
[O:1]=[C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:9][CH2:8]2)[C:5]2[CH:28]=[CH:29][CH:30]=[CH:31][C:4]=2[NH:3]1.NN.O>C(O)C>[O:1]=[C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH2:9][CH2:8]2)[C:5]2[CH:28]=[CH:29][CH:30]=[CH:31][C:4]=2[NH:3]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18187410HCID 18187410, compound

Product 1

HCID 18187426HCID 18187426, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Batch size: 11.5 g (27.4 mmol) 2-{4-[4-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-butyl}-isoindolin-1,3-dione and 2.7 ml (55 mmol) hydrazine.hydrate in 60 ml ethanol. The accumulated crude product is further processed without further purification: Yield 5.1 g (64%).

Workup

  1. customis further processed without further purification

Sources & evidence

ORD record
ord-b90cb24195e04d77bb404dcc919c6283
Source dataset
uspto-grants-2003_07
Patent number
US06593344B1

Reaction notes

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