HCID 18504111, compound → HCID 18504109, compound

HRID 1358137Notes

Reaction equation

HRID 1358137 reaction equation
Br[C:2]1[C:7]2[CH:8]([O:20][CH3:21])[O:9][C:10]3[C:15]([C:6]=2[CH:5]=[CH:4][C:3]=1[NH:22]C(=O)OCC1C=CC=CC=1)=[C:14]([O:16][CH:17]([F:19])[F:18])[CH:13]=[CH:12][CH:11]=3>[Pd].CO.C1COCC1>[F:19][CH:17]([F:18])[O:16][C:14]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]=1[C:6]1[CH:5]=[CH:4][C:3]([NH2:22])=[CH:2][C:7]=1[CH:8]([O:20][CH3:21])[O:9]2

Participants

5

Reactant 1

HCID 18504111HCID 18504111, compound

Product 1

HCID 18504109HCID 18504109, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of Example 96A (82 mg, 0.16mmol) and 10% palladium on carbon (8 mg) in methanol (10 ml) and THF (10 ml) was stirred under hydrogen gas for 1.5 hour, filtered through diatomaceous earth (Celite®), and concentrated to provide the desired product. MS (ESI(+)Q1MS) m/z 294 (M+H)+.

Workup

  1. filtrationfiltered through diatomaceous earth (Celite®)
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-42b0f1d4c9bf43e9bbce4765e2e4d9d9
Source dataset
uspto-grants-2003_07
Patent number
US06593480B2

Reaction notes

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