反应详情

A suspension of 29.4 mg (0.10 mmol) 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid and 18.4 mg (0.11 mmol) 1.1′-carbonyl-diimidazole in 3 ml dimethylformamide was stirred at room temperature for one hour. 12.1 μl (0.11 mmol) benzylamine were added, stirring was continued and after 20 hours 15 ml water were added. Extraction with ethyl acetate and chromatography on silicagel with dichloromethane/ethyl acetate 95/5 yielded 31.2 mg (41%) of yellow 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid benzylamide with mp.: 156-158° C., MS m/e (%): 384 (M+H+, 100).

1. stirringstirring
2. waitwas continued and after 20 hours
3. extractionExtraction with ethyl acetate and chromatography on silicagel with dichloromethane/ethyl acetate 95/5