Ethanesulfonyl chloride → Benzenesulfonamide

HRID 1358370Notes

Reaction equation

HRID 1358370 reaction equation
C([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14]C2C(OC3C=CC=CC=3OC)=C(OCCCN)N=C(C3CC3)N=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)(C)(C)C.C(S(Cl)(=O)=O)C>>[C:8]1([S:11]([NH2:14])(=[O:13])=[O:12])[CH:9]=[CH:10][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 18184175HCID 18184175, compound

Product 1

HCID 7370Benzenesulfonamide

Procedure

According to the procedure described in Example 4a) 200 mg p-tert.-butyl-N-[6-(3-aminopropoxy)-5-(o-methoxyphenoxy)-2-cyclopropyl-4-pyrimidinyl]benzene-sulfonamide was reacted with ethanesulfonylchloride to give 220 mg p-tert.-butyl-N-[6-(3-ethansulfonylamino)-propoxy)-5-(o-methoxyphenoxy)-2-cyclopropyl-4-pyrimidinyl]benzene-sulfonamide. LC-MS: tR=5.74 min, [M+1]+=619.22, [M−1]−=617.24.

Sources & evidence

ORD record
ord-319ecda79e6e4b9994fc55bc7e426c0a
Source dataset
uspto-grants-2003_07
Patent number
US06596719B1

Reaction notes

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