反应详情

DIEA (8.0 g) was added to a suspension of (1R,3S)-camphoric acid (5.0 g) and BOP Reagent (11.1 g) in THF (50 ml) at room temperature. The mixture was stirred for 4 hr. and the solvent was removed in vacuo. The residue was extracted with AcOEt and the extract was washed with 5% HCl, sat. NaHCO3, and sat. LiCl, and dried over Na2SO4. The solvent was removed in vacuo and the residue was purified by flash chromatography on silica gel (eluent; CHCl3) to give (1R)-camphoric anhydride (4.1 g) as a colorless powder.

1. customand the solvent was removed in vacuo
2. extractionThe residue was extracted with AcOEt
3. washthe extract was washed with 5% HCl, sat. NaHCO3, and sat. LiCl
4. dry with materialdried over Na2SO4
5. customThe solvent was removed in vacuo
6. customthe residue was purified by flash chromatography on silica gel (eluent; CHCl3)