HCID 21893489, compound → HCID 11381315, compound

HRID 1358664Notes

Reaction equation

HRID 1358664 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][C:9]([CH:12]([CH3:20])[CH2:13][NH:14][S:15]([CH:18]=[CH2:19])(=[O:17])=[O:16])=[CH:8][CH:7]=2)=[CH:2]1>[Pd].C(OCC)(=O)C>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[CH:8][C:9]([CH:12]([CH3:20])[CH2:13][NH:14][S:15]([CH2:18][CH3:19])(=[O:17])=[O:16])=[CH:10][CH:11]=2)=[CH:2]1

Participants

4

Reactant 1

HCID 21893489HCID 21893489, compound

Product 1

HCID 11381315HCID 11381315, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 0.024 g (0.078 mmol) of material from Example 130 and 5 mg 5% palladium on carbon in 5 mL ethyl acetate was degassed three times under a hydrogen balloon and stirred at room temperature for 4 hr. The mixture was filtered and concentrated in vacuo. The residue was recrystallized from ether and hexane to afford 0.024 g (99%) of the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo
  3. customThe residue was recrystallized from ether and hexane

Sources & evidence

ORD record
ord-dc662a6ceef44c95808beb2497c7d879
Source dataset
uspto-grants-2003_07
Patent number
US06596716B2

Reaction notes

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