反应详情

温度

100 °C

A mixture of 4-(3-hydroxyphenoxy)benzoic acid (100 mg, 0.434 mmol), 4-(trifluoromethylsulfonyl)chlorobenzene (106 mg, 1 equiv.) and potassium carbonate (240 mg, 4 equiv.) in DMF was heated to 100° C. overnight. The reaction was poured into water, extracted with EtOAc, washed the organic layer with water, brine, dried and concentrated. The residue was column chromatographed to give 4-[3-(4-trifluoromethanesulfonyl-phenoxy)-phenoxy]-benzoic acid. 1HNMR (300 MHz, DMSO-d6) δ 8.09 (d, J=8.97 Hz, 2H), 7.95 (d, J=8.94 Hz, 2H), 7.56 (t, J=8.54 Hz, 1H), 7.33 (d, J=8.94 Hz, 2H), 7.10 (d, J=8.97 Hz, 2H), 7.04-7.11 (m, 3H). MS-EI m/z 438 [M+].

1. extractionextracted with EtOAc
2. washwashed the organic layer with water, brine
3. customdried
4. concentrationconcentrated
5. customchromatographed