Sodium Bicarbonate → HCID 88116952, compound

HRID 1358915Notes

Reaction equation

HRID 1358915 reaction equation
[NH2:1][C:2]1[S:3][C:4]([Cl:32])=[C:5]([C:7](=[N:30][OH:31])[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[CH:12]2[S:13][CH2:14][C:15]([S:23][C:24]2[S:25][C:26]([NH2:29])=[N:27][N:28]=2)=[C:16]3[C:20]([OH:22])=[O:21])=[O:9])[N:6]=1.C(=O)(O)[O-].[Na+:37]>O>[Na+:37].[NH2:1][C:2]1[S:3][C:4]([Cl:32])=[C:5]([C:7](=[N:30][OH:31])[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[CH:12]2[S:13][CH2:14][C:15]([S:23][C:24]2[S:25][C:26]([NH2:29])=[N:27][N:28]=2)=[C:16]3[C:20]([O-:22])=[O:21])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 86585656HCID 86585656, compound

Product 1

HCID 88116952HCID 88116952, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(7R)-7-[2-(2-Amino-5-chlorothiazol-4-yl)-2-hydroxyiminoacetylamino]-3-(5-amino-[1,3,4]thiadiazol-2-ylsulfanyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (85 mg, 0.11 mmol) was dissolved in water (2.0 mL) and the pH was adjusted to 6.0 with 1.0 M aqueous sodium bicarbonate. The solution was loaded onto an HP20 column and inorganics were removed by washing the column thoroughly with water. The title compound was isolated by eluting with 2:1 acetonitrile/water, removing acetonitrile under reduced pressure and lyophilizing the remaining mixture (60 mg, 63%).

Workup

  1. customwere removed
  2. washby washing the column thoroughly with water

Sources & evidence

ORD record
ord-8e3533e90f40489dbda07d1b29d924f8
Source dataset
uspto-grants-2003_07
Patent number
US06599893B2

Reaction notes

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