Potassium Carbonate → HCID 178515855, compound

HRID 1359262Notes

Reaction equation

HRID 1359262 reaction equation
[CH2:1]([C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10]([O:15]C)[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>Br>[CH2:1]([C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10]([OH:15])[CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 18182261HCID 18182261, compound

Product 1

HCID 178515855HCID 178515855, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

250 ml of 47% hydrobromic acid was added to 62 g of 4-benzyl-5-bromo-2-methoxypyridine, followed by heating under stirring for 3 hours in an oil bath kept at 100° C. After cooling as it was, the reaction solution was added to an aqueous potassium carbonate solution little by little and neutralized. The resulting precipitates were collected by filtration, to give 59 g of the target compound.

Workup

  1. temperatureby heating
  2. customkept at 100° C
  3. temperatureAfter cooling as it
  4. customThe resulting precipitates
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-8c821cdfdc234599beec1c2f718899b5
Source dataset
uspto-grants-2003_07
Patent number
US06599917B1

Reaction notes

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