Hydrogen Bromide → HCID 178515815, compound

HRID 1359267Notes

Reaction equation

HRID 1359267 reaction equation
[CH2:1]([C:8]1[C:13]([Br:14])=[CH:12][CH:11]=[C:10]([O:15]C)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br>O>[CH2:1]([C:8]1[C:13]([Br:14])=[CH:12][CH:11]=[C:10]([OH:15])[N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 18182472HCID 18182472, compound

Product 1

HCID 178515815HCID 178515815, compoundYield 92.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 72.5 g of 2-benzyl-3-bromo-6-methoxypyridine and 300 ml of 47% hydrobromic acid was heated under stirring for 4 hours in an oil bath kept at 100° C. After cooling as it was, 500 ml of water was added thereto. The resulting crystals were collected by filtration, washed with water and diethyl ether, air-dried and then dried under heating under reduced pressure, to give 63.8 g of the target compound.

Workup

  1. temperaturewas heated
  2. customkept at 100° C
  3. temperatureAfter cooling as it
  4. filtrationThe resulting crystals were collected by filtration
  5. washwashed with water and diethyl ether
  6. customair-dried
  7. customdried
  8. temperatureunder heating under reduced pressure

Sources & evidence

ORD record
ord-f902d7eb8cf7490f9f8ce16adbe57692
Source dataset
uspto-grants-2003_07
Patent number
US06599917B1

Reaction notes

Loading…