反应详情

A mixture of 6.6 g of 2-benzyl-6-(3,3-ethylenedioxypyrrolidine-1-yl)pyridine and 60 ml of N,N-dimethylformamide was stirred in an ice bath. Into the mixture were added dropwise 5.5 g of N-iodosuccinimide, followed by stirring at room temperature overnight as it was. 10 ml of an aqueous solution containing one mol of sodium thiosulfate was added thereto, and the mixture was partitioned between ethyl acetate and water. The organic phase was washed with water and brine, dried over anhydrous magnesium sulfate and then concentrated. The residue was subjected to silica gel column chromatography using 5-10% ethyl acetate/hexane, to give 6.7 g of the target compound.

1. stirringby stirring at room temperature overnight as it
2. additionwas added
3. customthe mixture was partitioned between ethyl acetate and water
4. washThe organic phase was washed with water and brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated