反应详情

190 mg of 60% oily sodium hydride and 0.3 ml of methyl iodide were added to a solution of 1.67 g of 4-benzyl-5-bromo-2-[(3R,4R)-3,4-dihydroxypyrrolidine-1-yl]pyridine in tetrahydrofuran, followed by stirring for 6 hours. Then, the reaction solution was extracted with ethyl acetate-water, and the organic phase was washed with water and brine, dried over anhydrous magnesium sulfate and evaporated. The residue was subjected to silica gel column chromatography and eluted with 50% ethyl acetate, to give 560 mg of the target compound.

1. extractionThen, the reaction solution was extracted with ethyl acetate-water
2. washthe organic phase was washed with water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customevaporated
5. washeluted with 50% ethyl acetate