反应详情

16.1 ml of an aqueous 29% ammonia solution was added to a mixture of 5.0 g of 2-nitro-4-bromobenzaldehyde, 60.4 g of iron (II) sulfate heptahydrate, 200 ml of methanol, 100 ml of water and 335 μl of concentrated hydrochloric acid in an oil bath kept at 90° C., followed by heating under stirring for 10 minutes. After cooling as it was, insoluble matters were filtered through Celite and the filtrate was extracted with ethyl acetate. The organic phase was washed with brine and the solvent was removed, to give 3.9 g of the target compound.

1. customkept at 90° C.
2. temperatureby heating
3. temperatureAfter cooling as it
4. filtrationinsoluble matters were filtered through Celite
5. extractionthe filtrate was extracted with ethyl acetate
6. washThe organic phase was washed with brine
7. customthe solvent was removed