Hydrochloric Acid → HCID 22350364, compound

HRID 1359628Notes

Reaction equation

HRID 1359628 reaction equation
[CH3:1][C:2]1[S:6][C:5]([C:7]2[S:8][C:9]([C:12]([O:14]C)=[O:13])=[CH:10][CH:11]=2)=[CH:4][CH:3]=1.[Li+].[OH-].Cl>O1CCOCC1>[CH3:1][C:2]1[S:6][C:5]([C:7]2[S:8][C:9]([C:12]([OH:14])=[O:13])=[CH:10][CH:11]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 22350424HCID 22350424, compound

Product 1

HCID 22350364HCID 22350364, compoundYield 86.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The product of Step 14a (0.37 g, 1.54 mmol), dioxane (5 mL) and LiOH (1N, 3.1 mL, 3.1 mmol) are placed in a flask. Additional dioxane (5 mL) is then added for solubility and stirred for 24 h at rt. 1N HCl is added slowly until pH<6, whereupon a precipitate forms. The precipitate is then collected by filtration, rinsed with water, and dried in a 70° C. vacuum oven to provide the product as a yellow solid (0.30 g, 86%). MS for C10H8O2S2 (ESI) (M−H)+ m/z 223.

Workup

  1. filtrationThe precipitate is then collected by filtration
  2. washrinsed with water
  3. customdried in a 70° C. vacuum oven

Sources & evidence

ORD record
ord-72665ae311ac443cb54a4cc16b69863d
Source dataset
uspto-grants-2003_07
Patent number
US06599916B2

Reaction notes

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