5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one → HCID 59077570, compound

HRID 1359763Notes

Reaction equation

HRID 1359763 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=[O:12])=[O:11].[OH:23][C@@H:24]1[CH2:28][CH2:27][N:26]([CH2:29][C:30]2[C:31]([CH3:38])=[C:32]([CH:36]=O)[NH:33][C:34]=2[CH3:35])[CH2:25]1>C(O)C.N1CCCCC1>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])/[C:16]/2=[CH:36]\[C:32]1[NH:33][C:34]([CH3:35])=[C:30]([CH2:29][N:26]2[CH2:27][CH2:28][C@@H:24]([OH:23])[CH2:25]2)[C:31]=1[CH3:38])(=[O:12])=[O:11]

Participants

5

Reactant 2

HCID 181797685-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-oneHCID 88094453HCID 88094453, compound

Product 1

HCID 59077570HCID 59077570, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8082PiperidineSolvent

Procedure

5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one was condensed with 4-((R)-3-hydroxy-pyrrolidin-1-ylmethyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde in ethanol and piperidine to give the titled compound as a yellow solid.

Sources & evidence

ORD record
ord-c89e676b1a1443bd88fdc9bf56536ff6
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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