反应详情

A mixture of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (270 mg, 1.61 mmol), cyclopropyl-(S)-1-pyrrolidin-2-ylmethyl-amine (220 mg, 1.57 mmol), HOBt (199 mg, 1.47 mmol), EDAC (344 mg, 1.8 mmol) and TEA (0.5 mL) in DMF (7 mL) was stirred at rt for 48 hours. The reaction was concentrated, diluted with sodium bicarbonate and extracted with DCM. The combined DCM was dried, concentrated and filtered through silica gel to give 4-((S)-2-cyclopropylaminomethyl-pyrrolidine-1-carbonyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde.

1. concentrationThe reaction was concentrated
2. additiondiluted with sodium bicarbonate
3. extractionextracted with DCM
4. dry with materialThe combined DCM was dried
5. concentrationconcentrated
6. filtrationfiltered through silica gel