HCID 18179750, compound → HCID 59077551, compound

HRID 1359799Notes

Reaction equation

HRID 1359799 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=[O:12])=[O:11].[C:23]([N:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]2[C:34]([CH3:41])=[C:35]([CH:39]=O)[NH:36][C:37]=2[CH3:38])[CH2:28][CH2:27]1)(=[O:25])[CH3:24]>C(O)C.N1CCCCC1>[C:23]([N:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]2[C:34]([CH3:41])=[C:35](/[CH:39]=[C:16]3\[C:17](=[O:22])[NH:18][C:19]4[C:15]\3=[CH:14][C:13]([S:10]([CH2:9][C:3]3[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=3[Cl:8])(=[O:12])=[O:11])=[CH:21][CH:20]=4)[NH:36][C:37]=2[CH3:38])[CH2:28][CH2:27]1)(=[O:25])[CH3:24]

Participants

5

Reactant 2

HCID 18179750HCID 18179750, compoundHCID 181797685-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one

Product 1

HCID 59077551HCID 59077551, compound

Reagents, catalysts & solvents 2

HCID 8082PiperidineCatalystHCID 702EthanolSolvent

Procedure

5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one (357 mg, 1 mmol) was condensed with 4-(4-acetyl-piperazin-1-ylmethyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde (263 mg, 1 mmol) in ethanol (3 mL) and piperidine (3 drops) at 95-100° C. for 2 hours to give the titled compound.

Sources & evidence

ORD record
ord-d875abf9856648e69c45213096ba143f
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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