HCID 69995593, compound → HCID 45115983, compound

HRID 1359862Notes

Reaction equation

HRID 1359862 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13](=[O:19])[N:14]([CH:16]1[CH2:18][CH2:17]1)[CH3:15])=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH:16]1([N:14]([CH3:15])[C:13]([C@H:9]2[CH2:10][CH2:11][CH2:12][NH:8]2)=[O:19])[CH2:18][CH2:17]1

Participants

4

Reactant 1

HCID 69995593HCID 69995593, compound

Product 1

HCID 45115983HCID 45115983, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of (R)-2-(cyclopropyl-methyl-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (958 mg, 3.57 mmol) in 50% TFA in DCM (5 mL) was stirred at rt for 4 hours. The reaction was concentrated and purified to give (R)-pyrrolidine-2-carboxylic acid cyclopropyl-methyl-amide.

Workup

  1. concentrationThe reaction was concentrated
  2. custompurified

Sources & evidence

ORD record
ord-25da2d766ea14bb89d2f6191a684152c
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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