Tetrahydrofuran → 1'-(2-cyclopropylethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 135988Notes

Reaction equation

HRID 135988 reaction equation
[CH2:59]1[O:60][CH2:61][CH2:62][CH2:63]1.[CH:1]1([CH2:4][CH2:5][N:6]2[C:7](=[O:27])[C:8]([CH2:15][OH:16])([c:17]3[cH:18][c:19]4[c:20]([cH:24][c:25]3[OH:26])[O:21][CH2:22][O:23]4)[c:9]3[cH:10][cH:11][cH:12][cH:13][c:14]32)[CH2:2][CH2:3]1.[O:47]=[C:48]([O:49][CH2:50][CH3:51])[N:52]=[N:53][C:54]([O:55][CH2:56][CH3:57])=[O:58].[c:28]1([P:29]([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[cH:42][cH:43][cH:44][cH:45][cH:46]1>>[CH:1]1([CH2:4][CH2:5][N:6]2[C:7](=[O:27])[C:8]3([c:9]4[cH:10][cH:11][cH:12][cH:13][c:14]42)[CH2:15][O:16][c:25]2[c:17]3[cH:18][c:19]3[c:20]([cH:24]2)[O:21][CH2:22][O:23]3)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 666425671-(2-cyclopropylethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 118498551'-(2-cyclopropylethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-25c12fab48e4430a9a728da70e5bb0c4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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