Piperidine → HCID 59077731, compound

HRID 1359888Notes

Reaction equation

HRID 1359888 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][S:10]([C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17](=[O:22])[CH2:16]3)(=[O:12])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH:23]([C:25]1[NH:29][C:28]([CH3:30])=[C:27]([C:31]([OH:33])=[O:32])[C:26]=1[CH3:34])=O.N1CCCCC1>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][S:10]([C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17](=[O:22])/[C:16]/3=[CH:23]\[C:25]2[NH:29][C:28]([CH3:30])=[C:27]([C:31]([OH:33])=[O:32])[C:26]=2[CH3:34])(=[O:12])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 110737925-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic AcidHCID 18180008HCID 18180008, compound

Product 1

HCID 59077731HCID 59077731, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5-(3,5-dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one (356 mg, 1 mmol), 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (167 mg) and piperidine (cat. amount) in ethanol was stirred at rt for 2 days. The reaction was concentrated and triturated with HCl (2M solution) to give the titled compound.

Workup

  1. concentrationThe reaction was concentrated
  2. customtriturated with HCl (2M solution)

Sources & evidence

ORD record
ord-30cfd5c7dbec4b618a98e977064d1af5
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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