Triethylamine → HCID 59483408, compound

HRID 1359933Notes

Reaction equation

HRID 1359933 reaction equation
[P:1]([Cl:16])(Cl)([O:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([Cl:11])=[CH:6][C:5]=1[CH:12]([CH3:14])[CH3:13])=[O:2].Cl.[CH2:18]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH2:23])[CH3:19].CCN(CC)CC>C(Cl)Cl>[Cl:16][P:1]([NH:23][C@H:22]([C:21]([O:20][CH2:18][CH3:19])=[O:25])[CH3:24])([O:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([Cl:11])=[CH:6][C:5]=1[CH:12]([CH3:13])[CH3:14])=[O:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2724356L-Alanine, ethyl ester, hydrochloride (1:1)HCID 59483417HCID 59483417, compound

Product 1

HCID 59483408HCID 59483408, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure described for Example 1, step 2, treatment of a solution in DCM (0.098 M) of 4-chloro-2-isopropyl-5-methylphenyl dichlorophosphate with L-alanine ethyl ester hydrochloride (1.0 eq.) and Et3N (2.0 eq.) provided the title compound as a colorless oil as a 1:1.35* mixture of diastereoisomers. 31P NMR (300 MHz, CD3OD): δ 8.5 and 8.8*.

Sources & evidence

ORD record
ord-7863db74bba348a29996a1e43f4b2acd
Source dataset
uspto-grants-2011_02
Patent number
US07879815B2

Reaction notes

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