Dimethylamine → HCID 3777056, compound

HRID 1359951Notes

Reaction equation

HRID 1359951 reaction equation
[CH3:1][NH:2][CH3:3].Br[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][CH:9]=1)=[O:7]>CO.O1CCCC1>[Br:14][C:11]1[CH:12]=[CH:13][C:8]([C:6](=[O:7])[CH2:5][N:2]([CH3:3])[CH3:1])=[CH:9][CH:10]=1

Participants

5

Reactant 2

HCID 674DimethylamineHCID 74544-Bromophenacyl bromide

Product 1

HCID 3777056HCID 3777056, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A 2.0 M solution of dimethylamine (0.5 mmol) in methanol was added to a solution of 2-bromo-1-(4-bromophenyl)ethanone (114.5 mg, 0.41 mmol) in tetrahydrofuran (2 ml), and the mixture was stirred at room temperature for 15 min. The solvent was removed by distillation, and the residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100) to give 84.7 mg (yield 86%) of the title compound.

Workup

  1. customThe solvent was removed by distillation
  2. customthe residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100)

Sources & evidence

ORD record
ord-6214718ed01d4645b58786adafe238e4
Source dataset
uspto-grants-2011_02
Patent number
US07879808B2

Reaction notes

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