反应详情

To a solution of [(4-pentenyloxy)carbonyl]-L-norleucine methyl ester (1.8 g, 7.0 mmol) in THF (5 mL) at RT was added 1M sodium hydroxide solution (5 mL). The reaction mixture was stirred at RT for 3 h. The reaction mixture was then worked up with EtOAc and 1M HCl. The organic layer was separated and washed with H2O, brine, dried over Na2SO4, filtered and concentrated to give [(4-pentenyloxy)carbonyl]-L-norleucine (1.4 g, 82% yield). 1H NMR (500 MHz, CD3OD) ppm: δ 5.82 (m, 1H), 5.05 (d, 1H), 4.98 (d, 1H), 4.86 (brs, 2H), 4.10 (m, 1H), 4.08 (t, 2H), 2.16 (q, 2H), 1.82 (m, 1H), 1.72 (m, 3H), 1.38 (m, 4H), 0.93 (t, 3H).

1. customThe organic layer was separated
2. washwashed with H2O, brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated