Dimethylformamide dimethyl acetal → HCID 66781557, compound

HRID 1360146Notes

Reaction equation

HRID 1360146 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH3:17])[NH:14][CH:13]([CH2:15][NH2:16])[CH2:12][O:11][CH2:10]2)=[CH:5][CH:4]=1.[CH3:18]OC(OC)N(C)C>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2([CH3:17])[CH2:10][O:11][CH2:12][CH:13]3[CH2:15][N:16]=[CH:18][N:14]23)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 66781649HCID 66781649, compound

Product 1

HCID 66781557HCID 66781557, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 31 mmol of C-[5-(4-methoxyphenyl)-5-methylmorpholin-3-yl]methylamine and 31 mmol of N,N-dimethylformamide dimethyl acetal in 50 ml of dichloromethane is heated to reflux for 6 hours. The reaction mixture is cooled to room temperature and evaporated. The crude title compound is obtained as a yellow oil from the residue and is employed without further purification in the next stage, Rf=0.17 (dichloromethane-methanol-25% aqueous ammonia solution 200:20:1), Rt=2.61 (gradient I)

Workup

  1. temperatureto reflux for 6 hours
  2. customevaporated

Sources & evidence

ORD record
ord-2b4fcc10ba604294afd8c6107a946504
Source dataset
uspto-grants-2011_02
Patent number
US07879847B2

Reaction notes

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