Methylamine → 4-[(Methylamino)methyl]benzoic acid

HRID 1360354Notes

Reaction equation

HRID 1360354 reaction equation
Br[CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH3:12][NH2:13]>>[CH3:12][NH:13][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 225994-(Bromomethyl)benzoic acid

Product 1

HCID 139222544-[(Methylamino)methyl]benzoic acid

Procedure

4-Bromomethyl-benzoic acid (5 g, 22.8 mmol) is treated with a methylamine solution (40%, 75 mL, 867 mmol) for 4 days at ambient temperature. The resulting mixture is evaporated and the residue purified by flash chromatography.

Workup

  1. customThe resulting mixture is evaporated
  2. customthe residue purified by flash chromatography

Sources & evidence

ORD record
ord-1ea9e60901ea41a9a6363976d7ace138
Source dataset
uspto-grants-2011_02
Patent number
US07879853B2

Reaction notes

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