Hydrochloric Acid → HCID 66963342, compound

HRID 1360356Notes

Reaction equation

HRID 1360356 reaction equation
C([NH:3][C:4]([C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][CH:8]=1)([CH3:6])[CH3:5])=O.O.[ClH:19]>O1CCOCC1>[ClH:19].[NH2:3][C:4]([C:7]1[CH:17]=[CH:16][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=1)([CH3:6])[CH3:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86087217HCID 86087217, compound

Product 1

HCID 66963342HCID 66963342, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

Ethyl 4-(1-formylamino-1-methyl-ethyl)-benzoate (2.97 g, 12.6 mmol) is added to a mixture of water (30 mL), dioxane (15 mL) and concentrated hydrochloric acid (3.01 mL, 36.1 mmol) and the mixture is heated to 100° C. for 12 h. The reaction mixture is evaporated and the residue is crystallized from ethanol.

Workup

  1. customThe reaction mixture is evaporated
  2. customthe residue is crystallized from ethanol

Sources & evidence

ORD record
ord-325229a10af0495fabd1b0c27a63e632
Source dataset
uspto-grants-2011_02
Patent number
US07879853B2

Reaction notes

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