Pyrrolidine → HCID 16064297, compound

HRID 1360670Notes

Reaction equation

HRID 1360670 reaction equation
Cl[C:2]1[N:3]2[C:8]([CH:9]=[CH:10][CH:11]=1)=[C:7]([C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:19])[C:6](=[O:20])[CH:5]=[CH:4]2.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1>>[Cl:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[C:7]1[C:6](=[O:20])[CH:5]=[CH:4][N:3]2[C:8]=1[CH:9]=[CH:10][CH:11]=[C:2]2[N:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 57700381HCID 57700381, compound

Product 1

HCID 16064297HCID 16064297, compound

Conditions

Temperature
90 °C

Procedure

A mixture of 6-chloro-1-(2,6-dichlorophenyl)-2H-quinolizin-2-one (Example 1, 15 mg) in pyrrolidine (0.5 mL) was heated to 90° C. for 2½ hr and then concentrated. The residue was purified by silica gel (methylene chloride/acetone=3/1) to give title compound as a yellow solid (12 mg).

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by silica gel (methylene chloride/acetone=3/1)

Sources & evidence

ORD record
ord-f4e692b223df4ce1b51a23d7bfc8d6c9
Source dataset
uspto-grants-2011_02
Patent number
US07879875B2

Reaction notes

Loading…