反应详情

Oil free sodium hydride suspended in THF was added iodomethane (0.06 mL) and 6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-7-(hydroxymethyl)-2H-quinolizin-2-one (Example 50, 40 mg) at 0° C. The mixture was warmed to room temperature and stirred for a couple of hours until reaction complete. The mixture was quenched with water, extracted with ethyl acetate, brine, dried over MgSO4 and concentrated. The residue was purified by silica gel (100% acetone) to give the title compound (22 mg).

1. customThe mixture was quenched with water
2. extractionextracted with ethyl acetate, brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customThe residue was purified by silica gel (100% acetone)