Triethylamine → HCID 178513231, compound

HRID 1360718Notes

Reaction equation

HRID 1360718 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[NH:10][C:11]2[CH:17]=[C:16]([C:18]#[N:19])[CH:15]=[CH:14][C:12]=2[N:13]=1.Cl.[NH2:21][OH:22].CCN(CC)CC>CCO>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[C:9]1[NH:10][C:11]2[CH:17]=[C:16]([C:18]([NH:21][OH:22])=[NH:19])[CH:15]=[CH:14][C:12]=2[N:13]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 66967004HCID 66967004, compound

Product 1

HCID 178513231HCID 178513231, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a 25 ml rbf was added 0.100 g (0.347 mmol) of 2-(2,6-Dichloro-phenyl)-3H-benzoimidazole-5-carbonitrile, 2 mL of EtOH, 0.0482 g (0.694 mmol) of hydroxylamine HCl, and 0.048 mL (0.694 mmol) of Et3N. It was allowed stir at 80° C., under reflux, for 4 h. It was reduced in vacuo and the crude was used directly in the next reaction. MS (m/z) 321.1 M (+1), tR=0.93, Meth 10

Workup

  1. temperatureunder reflux, for 4 h
  2. customthe crude was used directly in the next reaction

Sources & evidence

ORD record
ord-bb929965242641a49a51a53125c58f37
Source dataset
uspto-grants-2011_02
Patent number
US07879850B2

Reaction notes

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