Hydrochloric Acid → HCID 87219412, compound

HRID 1360847Notes

Reaction equation

HRID 1360847 reaction equation
[ClH:1].[O:2]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[S:20][C:19]([NH:21][C:22](=[O:35])[C@@H:23]([NH:27]C(=O)OC(C)(C)C)[CH2:24][CH2:25][CH3:26])=[N:18][CH:17]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(OCC)(=O)C>[ClH:1].[NH2:27][C@@H:23]([CH2:24][CH2:25][CH3:26])[C:22]([NH:21][C:19]1[S:20][C:16]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][O:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)=[CH:17][N:18]=1)=[O:35]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 91139919HCID 91139919, compound

Product 1

HCID 87219412HCID 87219412, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
20 °C

Procedure

25 ml of a solution of gaseous hydrochloric acid (4.5 M) in ethyl acetate are added dropwise at 0° C. to 5 g of tert-butyl (1S)-2-[(5-{2-[(phenoxy)-methyl]phenyl}-1,3-thiazol-2-yl)amino]-1-propyl-2-oxoethylcarbamate, obtained in step 1.6, in solution in 60 ml of ethyl acetate. The mixture is stirred for 18 hours at 20° C. The precipitate formed is filtered, rinsed twice with diethyl ether and dried to give 3 g of a white solid.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered
  3. washrinsed twice with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-45cdce0e32dd42dfbbda08d0d79eb43c
Source dataset
uspto-grants-2011_02
Patent number
US07879889B2

Reaction notes

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