Tetrahydrofuran → ethyl 4-[4-[[methyl(1,2,3,4-tetrahydro-1-naphthalenyl)amino]carbonyl]-2-thiazolyl]-alpha-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-beta-oxo-1-piperidinepropanoate
Reaction equation
[CH3:1][N:2]([C:3](=[O:4])[c:5]1[n:6][c:7]([CH:10]2[CH2:11][CH2:12][N:13]([C:16]([CH2:17][n:18]3[n:19][c:20]([C:24]([F:25])([F:26])[F:27])[cH:21][c:22]3[CH3:23])=[O:28])[CH2:14][CH2:15]2)[s:8][cH:9]1)[CH:29]1[CH2:30][CH2:31][CH2:32][c:33]2[cH:34][cH:35][cH:36][cH:37][c:38]21.[CH:39]([N-:40][CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[Cl:47][C:48](=[O:49])[O:50][CH2:51][CH3:52].[Li+:46].[O:53]1[CH2:54][CH2:55][CH2:56][CH2:57]1>>[CH3:1][N:2]([C:3](=[O:4])[c:5]1[n:6][c:7]([CH:10]2[CH2:11][CH2:12][N:13]([C:16]([CH:17]([n:18]3[n:19][c:20]([C:24]([F:25])([F:26])[F:27])[cH:21][c:22]3[CH3:23])[C:48](=[O:49])[O:50][CH2:51][CH3:52])=[O:28])[CH2:14][CH2:15]2)[s:8][cH:9]1)[CH:29]1[CH2:30][CH2:31][CH2:32][c:33]2[cH:34][cH:35][cH:36][cH:37][c:38]21Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-a3ba3e25c05b4ff998fdb1e8b626c726
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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