反应详情

温度

40 °C

2-Ethylindole (0.5 g, 3.4 mmol) dissolved in DMF (2 mL) was added to a cold (0° C.) premixed (30 minutes) mixture of DMF (1.15 mL) and phosphorous oxychloride (0.64 g, 4.16 mmol). After addition of 2-ethylindole, the mixture was heated to 40° C. for 1 h, water (5 mL) was added and the pH adjusted to 5 by means of 1 N sodium hydroxide. The mixture was subsequently extracted with diethyl ether, the organic phase isolated, dried with MgSO4 and evaporated to dryness affording 2-ethylindole-3-carbaldehyde (300 mg).

1. additionwas added to a cold (0° C.)
2. additionpremixed
3. extractionThe mixture was subsequently extracted with diethyl ether
4. customthe organic phase isolated
5. dry with materialdried with MgSO4
6. customevaporated to dryness