反应详情

温度

125 °C

A mixture of 4-aminobenzonitrile (10 g, 84.6 mmol), sodium azide (16.5 g, 254 mmol) and ammonium chloride (13.6 g, 254 mmol) in DMF was heated at 125° C. for 16 hours. The cooled mixture was filtered and the filtrate was concentrated in vacuo. The residue was added water (200 mL) and diethyl ether (200 mL) which resulted in crystallisation. The mixture was filtered and the solid was dried in vacuo at 40° C. for 16 hours to afford 5-(4-aminophenyl)-2H-tetrazole.

1. filtrationThe cooled mixture was filtered
2. concentrationthe filtrate was concentrated in vacuo
3. additionThe residue was added water (200 mL) and diethyl ether (200 mL) which
4. customresulted in crystallisation
5. filtrationThe mixture was filtered
6. customthe solid was dried in vacuo at 40° C. for 16 hours