Oxalyl chloride → 2,2-Dimethyl-3-acetyloxypropionyl chloride

HRID 1361293Notes

Reaction equation

HRID 1361293 reaction equation
[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:15])=O>C1C=CC=CC=1>[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3]([Cl:15])=[O:4]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 131926213-(Acetyloxy)-2,2-dimethylpropanoic acid2×

Product 1

HCID 111946632,2-Dimethyl-3-acetyloxypropionyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
0 °C

Procedure

The product of Step A, 2,2-dimethyl-3-acetyloxypropionic acid (11.76 g, 80 mmol) was dissolved in benzene (100 mL), the reaction solution was cooled 0° C., oxalyl chloride (15.0 g, 120 mmol) was slowly added dropwise. After 3 h, the solvent was removed in vacuo, and distilled in vacuo to give the title compound.

Workup

  1. customthe solvent was removed in vacuo
  2. distillationdistilled in vacuo

Sources & evidence

ORD record
ord-4b5c65602ce6420b89b9f21bf9c0db30
Source dataset
uspto-grants-2011_02
Patent number
US07879852B2

Reaction notes

Loading…