反应详情

温度

0 °C

2.74 g (9.033 mmol) of polyhydroxymaleimide-polyhydroxystyrene was dissolved in 50 ml of N-methylpyrrolidone (NMP), cooled to 0° C., added with 3.291 g (32.52 mmol) of triethylamine (Et3N), stirred for 30 min, added with 6.995 g (21.679 mmol) of (1) 3,4-difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl ester, and then stirred at room temperature for 4 hours. The reaction solution was poured into water and methanol, after which the resulting solid was filtered. The solid was washed several times with water and then vacuum dried, thus obtaining the desired compound (2) (about 60% yield).

1. stirringstirred at room temperature for 4 hours
2. filtrationafter which the resulting solid was filtered
3. washThe solid was washed several times with water
4. customvacuum dried