反应详情

Iron powder (72.7 g), 251 mL of ethanol, 103 mL of distilled water, and 0.55 mL of 35% hydrochloric acid were mixed together, and the mixture was heated to reflux. Subsequently, a solution of 66.9 g of 4-nitro-1-(4-trifluoromethoxyphenoxy)-2-trifluoromethylbenzene dissolved in 77 mL of ethanol was added dropwise to the mixed solution, and the mixture was heated under reflux for 2.5 hr. The reaction solution was cooled to room temperature, sodium bicarbonate water was added thereto, and the mixture was filtered. The filtrate was concentrated under the reduced pressure, and ethyl acetate and brine were added to the residue, followed by separation. The ethyl acetate layer was washed with brine and was then concentrated under the reduced pressure to give 61.0 g of 4-(4-trifluoromethoxyphenoxy)-3-trifluoromethylaniline (yield 99%).

1. temperaturethe mixture was heated to reflux
2. additionwas added dropwise to the mixed solution
3. temperaturethe mixture was heated
4. temperatureunder reflux for 2.5 hr
5. filtrationthe mixture was filtered
6. concentrationThe filtrate was concentrated under the reduced pressure, and ethyl acetate and brine
7. additionwere added to the residue
8. customfollowed by separation
9. washThe ethyl acetate layer was washed with brine
10. concentrationwas then concentrated under the reduced pressure