1,2-Dichloro-4-nitrobenzene → HCID 1241310, compound

HRID 1361465Notes

Reaction equation

HRID 1361465 reaction equation
C(=O)([O-])[O-].[K+].[K+].CN(C)C(=O)C.Cl[C:14]1[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=1[Cl:23].[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([SH:31])=[CH:27][CH:26]=1>O>[Cl:23][C:15]1[CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=[CH:19][C:14]=1[S:31][C:28]1[CH:29]=[CH:30][C:25]([Cl:24])=[CH:26][CH:27]=1

Participants

6

Reactant 4

HCID 74431,2-Dichloro-4-nitrobenzeneHCID 7815p-ChlorothiophenolHCID 11430Potassium CarbonateHCID 31374Dimethylacetamide

Product 1

HCID 1241310HCID 1241310, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
37.5 °C

Procedure

Potassium carbonate (10.4 g) was added to a mixture composed of 50 mL of N,N-dimethylacetamide, 19.2 g of 1,2-dichloro-4-nitrobenzene, and 14.5 g of 4-chlorobenzenethiol. This mixed solution was stirred at 35 to 40° C. for 2.5 hr. This reaction solution was poured into 500 mL of iced water, and the precipitated crystals were collected by filtration to give 27.8 g of 2-chloro-1-(4-chlorophenylthio)-4-nitrobenzene (yield 92.5%).

Workup

  1. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-4dba86af0a7e4016a1f09b738ee6dc76
Source dataset
uspto-grants-2011_02
Patent number
US07880006B2

Reaction notes

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